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With help from the ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.


Phase III Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  A prospective, multicenter, randomized, double-blind, placebocontrolled, parallel group, phase 2 study to compare the efficacy and safety of masitinib versus placebo in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
2.  A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment With MYOBLOC® (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Parkinson's Disease


Phase II Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
2.  Clinical Trial Phase I/II, Randomized, Controlled With Placebo, Triple Blind to Evaluate Safety, and Indications of Efficiency of the Intravenous Administration of the Therapy With 3 Doses of MSC in Patients With ASL Moderated to Severe Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS
3.  A Registry-Based Randomized-Controlled, Double-Blinded Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  Phase 2 Study of Rasagiline for Treatment of Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  Electronic-health Application To Measure Outcomes REmotely Clinical Trial Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
6.  Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
7.  Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS) In Participants with Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Other Interventional Trials:

  Trial Name Study Status Disease Categories
1.  Developing a Discrimination Model to Diagnose ALS Using Advanced MRI Techniques Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
2.  Paired Stimulation to Increase Cortical Transmission to Hand Muscles: Pilot Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
3.  Metabotropic Glutamate Receptor 5 (mGluR5) Imaging in Amyotrophic Lateral Sclerosis (ALS) Patients and Healthy Volunteers Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
4.  Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
5.  A Pilot Study of Inosine in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
6.  Determining the Safety of L-serine in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
7.  Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
8.  BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP)
9.  Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS, Other: Assessment of Care
10.  Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
11.  Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
12.  A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
13.  HDE Post-Approval Study (PAS) of NeuRx DPS for ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
14.  Initiation of Long-term Home Non-invasive Ventilation in ALS Using the iVAPS Mode During a Daytime Trial Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Observational Studies:

  Trial Name Study Status Disease Categories
1.  A Multi-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-Directed Biomedical Research Initiatives Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other: All Diagnosed Health Conditions
2.  Neurogenic Dysphonia/Dysphagia Registry Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
3.  Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
4.  Quantitative Ultrasonography and Electrical Impedance Myography: Speech and Swallowing Technologies for Use in Neurological Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
5.  Clinical Research in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
6.  PRE-Symptomatic Studies in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
7.  Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other: Muscular Dystrophy, Radiculopathy, Myopathy, Polyneuropathy and Mononeuropathies
8.  Accurate Test of Limb Isometric Strength (ATLIS) in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
9.  Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
10.  Establishment of a Tissue Bank (Blood, CSF) for the Understanding of the Disease Progression and Early Diagnosis of Motor Neuron Disease (MND) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
11.  A Multi-Center Longitudinal Biorepository Study to Provide Biospecimens & Clinical Data From Neurological Disease Patients To Approved Pre-Clinical And Clinical Investigators for Drug & Biomarker Studies Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
12.  Identification of Diagnostic and Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
13.  Phenotype, Genotype & Biomarkers in ALS and Related Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
14.  Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2 Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
15.  Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
16.  Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Frontotemporal Dementia (FTD)
17.  The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS
18.  Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS
19.  Non-Invasive Measurement of GI Motility in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer
20.  Familial Amyotrophic Lateral Sclerosis (FALS) Study Active, currently recruiting Healthy Volunteer with a Family History of ALS
21.  ALS Tissue Donation Program Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
22.  EEG-Based Brain-Computer Interface Project for Individuals With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
23.  Family Studies in Neuromuscular Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
24.  PRISM Registry: Pseudobulbar Affect Registry Series Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
25.  A Multicenter Study for the Discovery and Validation of ALS Biomarkers Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
26.  Clinical and Molecular Manifestations of Inherited Neurological Disorders Active, currently recruiting Familial ALS
27.  UW/VA Madison Brain Bank Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
28.  Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
29.  Screening and Natural History: Primary Lateral Sclerosis and Related Disorders Active, currently recruiting Primary Lateral Sclerosis (PLS)
30.  Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression Active, currently recruiting Primary Lateral Sclerosis (PLS)
31.  DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
32.  Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
33.  Stem Cells for Research in Motor Neuron Disease Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
34.  Analysis of Immune Activation in the Peripheral Blood of Patients with ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
35.  The National Amyotrophic Lateral Sclerosis Registry Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
36.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
37.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS


 
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