Member Portal    
 
  Clinical
ALS Trials
Trials
Browse Recruiting Trials
Search for a Trial
Clinical Trial News
Clinical Trials 101
Questions about Clinical Research?
Contact an ALS Trial Liaison


Call or email us with your questions
about clinical research

(877) 458-0631
alstrials@partners.org
 

Browse Recruiting Trials

 
With help from the ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.


Phase III Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment With MYOBLOC® (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Parkinson's Disease


Phase II Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
2.  Safety and Efficacy on Spasticity Symptoms of a Cannabis Sativa Extract in Motor Neuron Disease (CANALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
3.  Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Familial ALS
4.  Randomized Double Blind Placebo Controlled Cross-Over Study of Incobotulinum Toxin A (Xeomin®) for Troublesome Sialorrhea in Parkinson's Disease and ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  The Experimental Treatment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
6.  Phase IIa Double-Blind, Placebo-Controlled Study to Evaluate the Safety of Oral Fingolimod in Patients With Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
7.  A Safety and Tolerability Study of Mexiletine in Patients with Sporadic ALS (SALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS
8.  A Novel Immunosuppression Intervention for the Treatment of Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
9.  Efficacy, Safety and Tolerability Study of 1 mg Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS) Receiving Standard Therapy (Riluzole) - An AMG Trial With a Market Authorized Substance Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
10.  Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS) In Participants with Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
11.  A Study to Explore the Safety and Tolerability of Acthar in Patients With Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
12.  A prospective, multicenter, randomized, double-blind, placebocontrolled, parallel group, phase 2 study to compare the efficacy and safety of masitinib versus placebo in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Other Interventional Trials:

  Trial Name Study Status Disease Categories
1.  Safety Study of VM202 to Treat Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
2.  Determining the Safety of L-serine in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
3.  Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  Supported Treadmill Ambulation Training (STAT) for Patients Diagnosed With Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS Active, currently recruiting Familial ALS
6.  A Randomized Crossover Study of Standard, Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in Amyotrophic Lateral Sclerosis (ALS) Patients Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
7.  BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP)
8.  Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS, Other: Assessment of Care
9.  Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
10.  Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
11.  A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
12.  HDE Post-Approval Study (PAS) of NeuRx DPS for ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
13.  Intra-spinal Cord Delivery of Human Neural Stem Cells in ALS Patients: Proposal for a Phase I Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Observational Studies:

  Trial Name Study Status Disease Categories
1.  Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Frontotemporal Dementia (FTD)
2.  Pre-familial Amyotrophic Lateral Sclerosis (Pre-fALS) study Active, currently recruiting Healthy Volunteer with a Family History of ALS
3.  Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS
4.  Non-Invasive Measurement of GI Motility in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer
5.  Familial Amyotrophic Lateral Sclerosis (FALS) Study Active, currently recruiting Healthy Volunteer with a Family History of ALS
6.  ALS Tissue Donation Program Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
7.  Quantitative Measurement of Nutritional Substrate Utilization in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
8.  EEG-Based Brain-Computer Interface Project for Individuals With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
9.  Family Studies in Neuromuscular Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
10.  PRISM Registry: Pseudobulbar Affect Registry Series Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
11.  Discovery and Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-02) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
12.  Clinical and Molecular Manifestations of Inherited Neurological Disorders Active, currently recruiting Familial ALS
13.  UW/VA Madison Brain Bank Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
14.  Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
15.  Screening and Natural History: Primary Lateral Sclerosis and Related Disorders Active, currently recruiting Primary Lateral Sclerosis (PLS)
16.  Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression Active, currently recruiting Primary Lateral Sclerosis (PLS)
17.  DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
18.  Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
19.  Skin Biopsies for Research in Motor Neuron Diseases Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
20.  Analysis of Immune Activation in the Peripheral Blood of Patients with ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
21.  The National Amyotrophic Lateral Sclerosis Registry Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
22.  Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
23.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
24.  Longitudinal Study Comparing the Responsiveness of Outcomes Measures in ALS Trials Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
25.  The Natural History of SOD1 Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Familial ALS
26.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS


 
For Patients & Families
Educational Webinars
Online NEALS Resources
Other Resources
Contact a Disease Specialist
Clinical Research Blog

For Researchers
Become a NEALS member
Post an ALS Clinical Trial
NEALS CRO Capabilities
Annual NEALS Meeting
NEALS Samples
NEALS Historical Data
ALS Trials
Browse Recruiting Trials
Search for a Trial
Clinical Trial News
Clinical Trials 101

Get Involved
Donate samples
Donate to our Clinical Research
About Us
Our Mission
Our Structure
Our Research
NEALS Members
Motor Neuron Disease
Connect with us: Member Portal       Donate Now!       Help       Sitemap       Contact Us