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With help from the ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.


Phase III Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  A prospective, multicenter, randomized, double-blind, placebocontrolled, parallel group, phase 2 study to compare the efficacy and safety of masitinib versus placebo in the treatment of patients suffering from Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
2.  A Phase 3, Multicenter, Double-Blind, Placebo-Controlled, Single-Treatment Efficacy and Safety Study of MYOBLOC® (Part A) Followed by Open-Label, Multiple-Treatment With MYOBLOC® (Part B) in the Treatment of Troublesome Sialorrhea in Adult Subjects Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Parkinson's Disease


Phase II Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  A Phase 2, Randomized, Double Blind, Placebo Controlled Multicenter Study to Evaluate Safety and Efficacy of Transplantation of Autologous Mesenchymal Stem Cells Secreting Neurotrophic Factors (MSC-NTF) in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
2.  Electronic-health Application To Measure Outcomes REmotely Clinical Trial Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
3.  Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
4.  Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS) In Participants with Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Other Interventional Trials:

  Trial Name Study Status Disease Categories
1.  A Pilot Study of Inosine in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
2.  Determining the Safety of L-serine in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
3.  Effect of Noninvasive Positive Pressure Ventilation on Pulmonary Function Testing in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  Phase I/II Study of SOD1 Inhibition by Pyrimethamine in Familial ALS Active, currently recruiting Familial ALS
5.  BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP)
6.  Trial of Ascertaining Individual Preferences for Loved One's Role in End-of-Life Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS, Other: Assessment of Care
7.  Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
8.  Coping Effectiveness Training for Recently Diagnosed ALS Patients and Care Partners Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
9.  A Dose-escalation Safety Trial for Intrathecal Autologous Mesenchymal Stem Cell Therapy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
10.  HDE Post-Approval Study (PAS) of NeuRx DPS for ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
11.  Initiation of Long-term Home Non-invasive Ventilation in ALS Using the iVAPS Mode During a Daytime Trial Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Observational Studies:

  Trial Name Study Status Disease Categories
1.  Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Frontotemporal Dementia (FTD)
2.  Pre-familial Amyotrophic Lateral Sclerosis (Pre-fALS) study Active, currently recruiting Healthy Volunteer with a Family History of ALS
3.  Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS
4.  Non-Invasive Measurement of GI Motility in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer
5.  Familial Amyotrophic Lateral Sclerosis (FALS) Study Active, currently recruiting Healthy Volunteer with a Family History of ALS
6.  ALS Tissue Donation Program Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
7.  EEG-Based Brain-Computer Interface Project for Individuals With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
8.  Family Studies in Neuromuscular Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
9.  PRISM Registry: Pseudobulbar Affect Registry Series Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
10.  Discovery and Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-02) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
11.  Clinical and Molecular Manifestations of Inherited Neurological Disorders Active, currently recruiting Familial ALS
12.  UW/VA Madison Brain Bank Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
13.  Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
14.  Screening and Natural History: Primary Lateral Sclerosis and Related Disorders Active, currently recruiting Primary Lateral Sclerosis (PLS)
15.  Multicenter PLS Cohort Study of Oxidative Stress and Disease Progression Active, currently recruiting Primary Lateral Sclerosis (PLS)
16.  DNA, Blood and Skin Cell Repository for Research on ALS and Related Neurodegenerative Disorders at Mayo Clinic Florida Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
17.  Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
18.  Stem Cells for Research in Motor Neuron Disease Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
19.  Analysis of Immune Activation in the Peripheral Blood of Patients with ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
20.  The National Amyotrophic Lateral Sclerosis Registry Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
21.  Ultrasonography in Amyotrophic Lateral Sclerosis as a Predictor of Disease Progression and Tool in Diagnosis: a Pilot Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
22.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Myography Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
23.  Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedance Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS


 
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