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With help from the ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by the ALS Association and/ or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This feature is updated regularly, so please check back. If you need support please contact our ALS Trial Expert.


Phase III Interventional Trials in ALS:



Phase II Interventional Trials in ALS:

  Trial Name Study Status Disease Categories
1.  A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) and Evidence of Elevated Systemic Inflammation Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
2.  Open-Label, Proof-of-Mechanism Trial of Ibudilast Treatment in people with Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
3.  A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  F 18 T807 Tau PET Imaging in Familial Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  Clinical Trial Phase I/II, Randomized, Controlled With Placebo, Triple Blind to Evaluate Safety, and Indications of Efficiency of the Intravenous Administration of the Therapy With 3 Doses of MSC in Patients With ASL Moderate to Severe Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS
6.  A Registry-Based Randomized-Controlled, Double-Blinded Clinical Trial of Pimozide in Patients With Neuromuscular Junction Transmission Dysfunction Due to Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
7.  A Phase 2A Biomarker Study of EPI-589 in Subjects With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
8.  A Phase 2 Randomized, Placebo Controlled Trial of Tocilizumab in ALS Subjects Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS
9.  Electronic-health Application To Measure Outcomes REmotely Clinical Trial (EAT MORE) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
10.  A Phase 2 Pharmacodynamic Trial of Ezogabine on Neuronal Excitability in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
11.  Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)


Other Interventional Trials:

  Trial Name Study Status Disease Categories
1.  A Single-Arm Prospective Investigation of the Effects of Laughter Therapy on Mood, Stress, and Self-Efficacy in People With Central Nervous System Disorders. Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS)
2.  A Phase I, Double-Blind, Randomized, Placebo-Controlled, Multicenter, Single Ascending-Dose Study to Determine Initial Safety, Tolerability, and Pharmacokinetic Parameters of GDC-0134 in Patients With Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
3.  A Phase 1, Placebo-Controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BIIB067 Administered to Adult Subjects With Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  Paired Stimulation to Increase Cortical Transmission to Hand Muscles: Pilot Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  Metabotropic Glutamate Receptor 5 (mGluR5) Imaging in Amyotrophic Lateral Sclerosis (ALS) Patients and Healthy Volunteers Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
6.  Cervical Spinal Cord Metabolism and Microstructure in Amyotrophic Lateral Sclerosis(ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
7.  BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP)
8.  Initiation of Long-term Home Non-invasive Ventilation in ALS Using the iVAPS Mode During a Daytime Trial Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


Observational Studies:

  Trial Name Study Status Disease Categories
1.  A Study to Evaluate the Sensitivity, Specificity, and Overall Accuracy of an Amyotrophic Lateral Sclerosis Diagnostic Test Developed by Iron Horse Diagnostics Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
2.  Genomic Translation for Amyotrophic Lateral Sclerosis Care Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
3.  Defining Clinical Characteristics in C9ORF72 ALS Patients Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
4.  Methodology Study of Novel Electrophysiological, Physical, and Imaging Outcome Measures to Assess the Progression of Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
5.  Microbiome Assessment in People with ALS (MAP ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
6.  Cross-Sectional ALS Biofluid Biomarker (CABB) Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other: Asymptomatic ALS Gene Carrier
7.  A Longitudinal Study of Imaging Biomarkers in Amyotrophic Lateral Sclerosis (ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
8.  Answer ALS: Individualized Initiative for ALS Discovery Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
9.  A Multi-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-Directed Biomedical Research Initiatives Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other: All Diagnosed Health Conditions
10.  Feasibility of a Consumer Based Accelerometer in Monitoring Outpatient Physical Activity: A Study in Patients With Cancer and Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Other: Prostate Cancer, Renal Cancer, Brain Cancer
11.  Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
12.  Quantitative Ultrasonography and Electrical Impedance Myography: Speech and Swallowing Technologies for Use in Neurological Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
13.  Clinical Research in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
14.  PRE-Symptomatic Studies in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
15.  Innovative Ultrasound Technology in Neuromuscular Disease (AQUIRe) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS, Other: Muscular Dystrophy, Radiculopathy, Myopathy, Polyneuropathy and Mononeuropathies
16.  Accurate Test of Limb Isometric Strength (ATLIS) in ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
17.  Establishment of a Tissue Bank (Blood, CSF) for the Understanding of the Disease Progression and Early Diagnosis of Motor Neuron Disease (MND) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
18.  Identification of Diagnostic and Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
19.  Phenotype, Genotype & Biomarkers in ALS and Related Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
20.  Rare Diseases Clinical Research Network Advancing Research and Treatment for Frontotemporal Lobar Degeneration [ARTFL]: Research Projects 1 & 2 Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
21.  Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis (TRACK-ALS) Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
22.  Natural History and Biomarkers of C9ORF72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Other: Frontotemporal Dementia (FTD)
23.  The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer with a Family History of ALS
24.  Identification of Genes Causing Familial ALS or Increasing Risk for Sporadic ALS and ALS With Frontotemporal Dementia and Understanding Disease Mechanism Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer with a Family History of ALS
25.  Non-Invasive Measurement of GI Motility in Patients With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Healthy Volunteer
26.  Familial Amyotrophic Lateral Sclerosis (FALS) Study Active, currently recruiting Healthy Volunteer with a Family History of ALS
27.  ALS Tissue Donation Program Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer, Healthy Volunteer with a Family History of ALS
28.  EEG-Based Brain-Computer Interface Project for Individuals With ALS Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Healthy Volunteer
29.  Family Studies in Neuromuscular Disorders Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
30.  A Multicenter Study for the Discovery and Validation of ALS Biomarkers Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
31.  Clinical and Molecular Manifestations of Inherited Neurological Disorders Active, currently recruiting Familial ALS
32.  Tracking Progression of Amyotrophic Lateral Sclerosis Active, currently recruiting Familial ALS, Healthy Volunteer with a Family History of ALS
33.  Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PET Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS)
34.  Stem Cells for Research in Motor Neuron Disease Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS, Primary Lateral Sclerosis (PLS), Hereditary Spastic Paraplegia (HSP), Healthy Volunteer, Healthy Volunteer with a Family History of ALS
35.  The National Amyotrophic Lateral Sclerosis Registry Active, currently recruiting Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS


 
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