Dr. Jeffrey Rothstein is currently Professor of Neurology and Neuroscience in the Department of Neurology at Johns Hopkins University. He is also Director for the Robert Packard Center for ALS Research at Johns Hopkins and co-Director of the ALS clinic at Johns Hopkins. He received his medical training, and PhD and research training at the University of Illinois and the University of Chicago. He trained in Neurology and Neuromuscular disease at Johns Hopkins University.

Dr. Rothstein is a neurologist and neurobiologist with a major commitment to investigations of mechanisms of neurodegeneration. He has been a strong proponent of the roles of excitotoxicity, mitochondrial dysfunction, protein aggregation, and oxidative stress in the pathogenesis of ALS. More specifically, he has proposed that abnormalities in glutamate transport contribute to the pathogenesis of cellular abnormalities that occur in motor neuron death. His laboratory studies the basic biology of membrane transporter, the cellular events that underlie regulation of transporters, and the development of novel drug- and cellular-based therapeutics targeted for both transporters and motor neuron death. He has developed both in vitro and in vivo models of motor neuron degeneration.