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A Multicenter Study for the Discovery and Validation of ALS Biomarkers

Study Focus:
The purpose of this study is to collect biofluid samples for the banking and usage in ALS research.
Amyotrophic Lateral Sclerosis (ALS), Sporadic ALS, Familial ALS
Study Category:
Study Status:
Active, currently recruiting
Not Applicable
Observational Study
Funding Source:
ALS Therapy Alliance
Study Chair(s)/Principal Investigator(s):
Merit Cudkowicz, MD, MSc (Massachusetts General Hospital)
James D. Berry, MD, MPH (Massachusetts General Hospital)
Robert Bowser, PhD (Barrow Neurological Institute)
Robert Brown, MD, D. Phil (UMASS)
Kevin Boylan, MD (Mayo Clinic Jacksonville)
Jonathan Glass, MD (Emory University)
David Lacomis, MD (University of Pittsburgh) ID:
NEALS Affiliated?
Study Summary:
The purpose of the research study is to collect blood samples and cerebrospinal fluid (CSF) from people with amyotrophic lateral sclerosis (ALS). These samples will be collected approximately every 4 months. Through comparison of these specimens, the researchers hope to learn more about the underlying cause of ALS, as well as find unique biological markers, which could be used to develop new therapies.
Participant Duration:
up to 36 months
# of Subjects:
up to 250
Enrollment Start Date:
Enrollment End Date:
Posting Last Modified Date:
Date Study Added to
More information:
Eligibility Criteria
Male & Female
Minimum Age:
Min Vital Capacity (% predicted normal):
Time since Symptom Onset:
Not applicable
Time since Diagnosis:
Not applicable
Can participants use Riluzole?
Coordinating Center
Contact Information
Daniela Grasso
Mass General Hospital
Neurological Clinical Research Institute (NCRI) 165 Cambridge Street, 6th Floor
Boston, Massachusetts 02114
Other Eligibility Criteria:
Inclusion Criteria:

Age 18 or older
Diagnosis of suspected, possible, probable or definite ALS according to El Escorial Criteria
Vital capacity (VC) at least 50 percent predicted
Able to undergo multiple lumbar punctures

Exclusion Criteria:

Abnormal CSF pressure or intracranial/intraspinal tumors
Use of anticoagulant medication that cannot be safely withheld
Bleeding disorders

This is a partial listing.

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