Search for a Trial

With help from The ALS Association, NEALS provides up-to-date information for finding both federally and privately funded clinical studies focusing on ALS and motor neuron diseases. You can locate both interventional trials, which examine if treatments are effective and safe under controlled environments, and observation trials, which examine people in more natural environments.

NEALS sources this database from public information posted on www.clinicaltrials.gov and other public websites. Therefore, not all trials included here are supported directly by The ALS Association and/or NEALS. Trials with a NEALS emblem are those in which NEALS has a supporting role. This database is updated regularly, so please check back. If you need support please contact our ALS Trial Expert at (877) 458-0631 or alstrials@partners.org.

Please fill out any combination of the fields below. Making a selection in each field is not required for a search and may in fact limit your search results.

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Study Factors

Disease:

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Riluzole Use:

Date Study Last Updated:

Date Study Posted:

Eligibility Factors

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Time Since Symptom Onset:

Vital Capacity:

Enter FVC Score (% predicated normal):


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Trial Name Coordinating Center Location Status
Human Neural Progenitor Cells Secreting Glial Cell Line-Derived Neurotrophic Factor (CNS10-NPC-GDNF) for the Treatment of Amyotrophic Lateral Sclerosisimage description Los Angeles, California
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Active, not yet recruiting
A Study to Evaluate the Sensitivity, Specificity, and Overall Accuracy of an Amyotrophic Lateral Sclerosis Diagnostic Test Developed by Iron Horse Diagnosticsimage description Cleveland, Ohio
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Active, currently recruiting
A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of NP001 in Subjects With Amyotrophic Lateral Sclerosis (ALS) and Evidence of Elevated Systemic Inflammationimage description
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Active, currently recruiting
Effect of Mexiletine on Cortical Hyperexcitability in Sporadic Amyotrophic Lateral Sclerosis (SALS)image description Boston, Massachusetts
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Active, currently recruiting
Fluid Biomarkers with Deep Phenotyping in Patients with ALSimage description Phoenix, Arizona
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Active, not yet recruiting
Open-Label, Proof-of-Mechanism Trial of Ibudilast Treatment in people with Amyotrophic Lateral Sclerosis (ALS)image description Boston, Massachusetts
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Active, currently recruiting
Defining Clinical Characteristics in C9ORF72 ALS Patientsimage description St. Louis, Missouri
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Active, currently recruiting
Microbiome Assessment in People with ALS (MAP ALS)image description Boston, Massachusetts
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Active, currently recruiting
Cross-Sectional ALS Biofluid Biomarker (CABB) Studyimage description Boston, Massachusetts
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Active, currently recruiting
Answer ALS: Individualized Initiative for ALS Discoveryimage description Boston, Massachusetts
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Active, currently recruiting
A Pilot Study of RNS60 in Amyotrophic Lateral Sclerosis (ALS)image description Boston, Massachusetts
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Active, currently recruiting
A Phase 3, Multi-National, Double-Blind, Randomized, Placebo-Controlled, Stratified, Parallel Group, Study to Evaluate the Safety, Tolerability and Efficacy of Tirasemtiv in Patients With Amyotrophic Lateral Sclerosis (VITALITY-ALS)image description
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Active, no longer recruiting
A Phase 2 Randomized, Placebo Controlled Trial of Tocilizumab in ALS Subjectsimage description Boston, Massachusetts
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Active, currently recruiting
A Pilot Study of Inosine in ALSimage description Boston, Massachusetts
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Closed
Noninvasive Assessment of Neuromuscular Disease Using Electrical Impedanceimage description Boston, Massachusetts
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Closed
Multi-Center, Randomized Controlled Study of the NeuRx® Diaphragm Pacing System™ (DPS) In Participants with Amyotrophic Lateral Sclerosis (ALS)image description Boston, Massachusetts
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Closed
The Natural History of SOD1 Amyotrophic Lateral Sclerosisimage description St. Louis, Missouri
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Closed
A Novel Immunosuppression Intervention for the Treatment of Amyotrophic Lateral Sclerosis (ALS)image description Boston, Massachusetts
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Closed
Longitudinal Study Comparing the Responsiveness of Outcomes Measures in ALS Trialsimage description Boston, Massachusetts
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Closed
A Safety and Tolerability Study of Mexiletine in Patients with Sporadic ALS (SALS)image description Boston, Massachusetts
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Closed
Phase IIa Double-Blind, Placebo-Controlled Study to Evaluate the Safety of Oral Fingolimod in Patients With Amyotrophic Lateral Sclerosisimage description Boston, Massachusetts
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Closed
The Experimental Treatment of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis (ALS)image description Boston, Massachusetts
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Closed
Imaging and BioFluid Biomarkers in Amyotrophic Lateral Sclerosis (TRACK-ALS)image description Boston, Massachusetts
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Active, currently recruiting
Electronic-health Application To Measure Outcomes REmotely Clinical Trial (EAT MORE)image description Boston, Massachusetts
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Active, currently recruiting
A Phase 2 Pharmacodynamic Trial of Ezogabine on Neuronal Excitability in Amyotrophic Lateral Sclerosisimage description Boston, Massachusetts
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Active, currently recruiting
Ibudilast (MN-166) in Subjects With Amyotrophic Lateral Sclerosis (ALS) (IBU-ALS-1201)image description Charlotte, North Carolina
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Active, no longer recruiting
Analysis of Immune Activation in the Peripheral Blood of Patients with ALSimage description Boston, Massachusetts
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Active, recruiting healthy subjects only
Stem Cells for Research in Motor Neuron Diseaseimage description Boston, Massachusetts
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Active, currently recruiting
Magnetic Resonance Spectroscopy in Amyotrophic Lateral Sclerosisimage description Charlestown, Massachusetts
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Closed
Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)image description Baltimore, Maryland
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Closed
A Multicenter Study for the Discovery and Validation of ALS Biomarkersimage description Boston, Massachusetts
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Active, currently recruiting
A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in Amyotrophic Lateral Sclerosis (ALS)image description
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Closed
A Multicenter, Double-Blind, Placebo-Controlled, Study to Investigate the Safety and Efficacy of Lithium in Combination With Riluzole in Volunteers With Amyotrophic Lateral Sclerosis (ALS)image description , Massachusetts
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Closed
A Study of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS)image description Syracuse, New York
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Closed
Validation of a New Device to Measure Neuromuscular Disease Progressionimage description Charlestown, Massachusetts
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Closed
A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of the Safety and Efficacy of Dexpramipexole in Subjects With Amyotrophic Lateral Sclerosisimage description
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Closed
A Phase 1, Double-Blind, Placebo-Controlled, Dose-Escalation Study of the Safety, Tolerability, & Pharmacokinetics of ISIS333611 Administered Intrathecally to Patients w Familial Amyotrophic Lateral Sclerosis Due to Superoxide Dismutase 1 Gene Mutationimage description Charlestown, Massachusetts
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Closed
Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosisimage description Miami, Florida
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Active, no longer recruiting
Open-Label, Safety and Tolerability Extension Study of KNS-760704 in Amyotrophic Lateral Sclerosis (ALS) (CL211)image description Charlestown, Massachusetts
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Closed
Trial of High fat/High Calorie Diet versus Optimal Nutrition in Amyotrophic Lateral Sclerosisimage description Charlestown, Massachusetts
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Closed
The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Studyimage description Miami, Florida
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Active, currently recruiting
A Phase I, Open-label, First-in-human Feasibility and Safety Study of Human Spinal Cord derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosisimage description Charlestown, Massachusetts
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Closed
Validation of Biomarkers in Amyotrophic Lateral Sclerosis (ALS) (BIO_ALS-01)image description Boston, Massachusetts
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Closed
Clinical Trial for Ceftriaxone in Subjects with ALSimage description Charlestown, Massachusetts
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Closed
Phase 2 Selection Trial of High Dosage Creatine and Two Dosages of Tamoxifen in Amyotrophic Lateral Sclerosis (ALS)image description
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Closed
A Phase IIb, Multi-National, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Efficacy of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) (BENEFIT-ALS)image description
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Closed
Assessing Activation of Brain Microglia in ALS with Simultaneous MR-PETimage description Boston, Massachusetts
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Active, currently recruiting